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RMRC No. RMRC13201 Order
Strain/Stock Designation B6.129P2‐Adra2btm1(lacZ)Acch
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2015/12/18
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ： 1. homozygous mice are viable, but the frequency is lower (~15%) than expected; due to α2B‐AR deficiency in the placenta, neonates are prone to die after labor.
2. Characteristrics of homozygotes are as follows,
(A) The spatial expression pattern of α2B‐AR encoded by Adra2b is mapped to brain (septum, thalamus, cochlear nucleus, cerebellum), spinal cord (dorsal root ganglia) and placenta.
(B) α2B‐AR is colocalized with μ‐opioid receptor in the thalamus.
(C) Exhibit normal pain transmission.
(D) Exhibit normal morphine rewarding in conditional place preference, but is abnormal in naltrexone‐precipitated withdrawal syndromes
(E) the litter size is small
Depositor ：
Alice Chien Chang / 錢嘉韻
Email ：
Allele Symbol ： Adra2btm1(lacZ)Acch
Allele Name ：
Allele Description ：
Strain of Origin ： 129
Gene Symbol ： Adra2b
Gene Name ： adrenergic receptor, alpha 2b
Chromosome ： 2
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Neurobiology Research Pharmacology and Toxicology
Construction Technologies ：
LacZ
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		：
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由錢嘉韻教授所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Dr. Alice Chien Chang
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email:
Construct Map ：
 
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