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RMRC No.

RMRC13266

Order

Strain/Stock Designation

NOD-Tg(Lck-Ptpn22)CSytwu

Status

EM| (Cryopreserved Embryos)

Availability

Level4

Pricing

(Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD

Last Update Date

2017/9/1

Analysis Data

Description
Genes &
alleles
Phenotype
Health &
husbandry
References
Specific Term
and Conditions
Construct map

Species

：

laboratory mouse

Strain Type

：

COI (coisogenic strain),MSR (mutant strain)

Mutant Type

：

TG (Transgenic)

Other Names

：

Background Strain

：

NOD/Sytwu

Strain Description

：

1. cDNA of Ptpn22 is derived from NOD mouse splenocytes and subcloned into downstream of mouse distal Lck promoter.
2. dLck-HA-Ptpn22 is microinjected in to one-cell NOD embryos.
3. Ptpn22 is expressed mainly in lymphoid organs, such as the thymus, spleens, and PLNs.
4. The transgenic mice had a significantly lower incidence of spontaneous autoimmune diabetes, which was accompanied by fewer IFN-γ-producing T cells, and an increased ratio of CD4⁺Foxp3⁺ T_regsto CD4⁺INF-γ⁺or CD8⁺INF-γ⁺T cells, respectively, in pancreatic islets.
5. Decrease in number and pathogenic features of pancreas-infiltrating cells in this transgenic strain.

Depositor

：

Huey-Kang Sytwu

司徒惠康

：

sytwu@ndmctsgh.edu.tw

Allele Symbol	：	Tg(Lck-Ptpn22)CSytwu

Allele Name	：	Transgenic insertion C, Huey-Kang Sytwu

Allele Description	：






Strain of Origin	：	NOD/Sytwu

Gene Symbol	：	Ptpn22

Gene Name	：	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Chromosome	：	UN






Genotyping Method	：	Download
Genotyping NLAC	：

Research Application

：

Immunology and Inflammation

Diabetes and Obesity

Construction Technologies

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Animal Health Reports	：

Colony Maintenance Breeding & Husbandry	：

Colony Maintenance Mating System	：	hetero/hemi x wild type

References

：

PubMed ID: 23752610

Specific Terms of Use

：

有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.

分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.

Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.

分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由Dr. Huey-Kang Sytwu所提供

Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Dr. Huey-Kang Sytwu

分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email: sytwu@ndmctsgh.edu.tw

Construct Map

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