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RMRC No. RMRC13302 Order
Strain/Stock Designation C57BL/6-Apoeem1Narl/Narl
Status
LM| (Live Animal)
Availability Level3
Pricing International：300USD
Last Update Date 2023/3/22
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ：
Other Names ：
Background Strain ： C57BL/6JNarl
Strain Description ：
1.  Apoe mutant mouse was generated in C57BL/6JNarl background via CRISPR/Cas9 technology.
2.  Homozygote has higher serum cholesterol and triglyceride comparing to its heterozygous and wild type littermate.
3. Atherosclerosis occurs in homozygote with 8-12 weeks of age on high cholesterol diet.
4. Heterozygote has higher serum triglyceride comparing to its wild type littermate.
5. Phenotype data could be downloaded at the second genotyping method. 
Depositor ：
Chi-Kuang Leo Wang / 王繼廣
Email ： bujiii@nlac.narl.org.tw
Allele Symbol ： Apoeem1Narl
Allele Name ： endonuclease-mediated mutation 1, National Applied Research Laboratory
Allele Description ：
Strain of Origin ： C57BL/6JNarl
Gene Symbol ： Apoe
Gene Name ： apolipoprotein E
Chromosome ： 7
Genotyping Method ： Download    Download 2         
Genotyping NLAC ：            
Research Application ：
Cardiovascular Metabolism
Neurobiology Research Diabetes and Obesity
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： homo x homo
References ： PubMed ID: 35489334
PubMed ID: 35062051
PubMed ID: 35205118
Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由NLAC-NARL所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NLAC-NARL
Construct Map ：
 
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