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RMRC No. RMRC13313 Order
Strain/Stock Designation B6.129-Cdk12tm1.1Fmj/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2017/9/21
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1.  This strain is derived from homozygous B6.129-Cdk12tm1Fmj/Narl mated with Protamin-cre transgenic mice to remove loxP-flanked exon 3 and 4 of Cdk12 during spermatogenesis.
2.  The heterozygotes are viable and fertile, but homozygous deficiency in Cdk12 leads to embryonic lethality after implantation.
3.  The breeding scheme used in this strain is homozygousB6.129-Cdk12tm1Fmj/Narl(fl/fl) x heterozygousmutant (fl/-) and all are kept in C57BL/6J background.
Depositor ：
Ming-Ji Fann / 范明基
Email ： mjfann@ym.edu.tw
Allele Symbol ： Cdk12tm1.1Fmj
Allele Name ： cyclin-dependent kinase 12, target mutation 1.1, Ming-Ji Fann
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： Cdk12
Gene Name ： cyclin-dependent kinase 12
Chromosome ： 11
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Apoptosis Cell and Developmental Biology
Genetics Research
Construction Technologies ：
Cre-lox system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： B6.129-Cdk12/Narl (homo) x heterozygous
References ： PubMed ID: 26658019

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： Cdk12 is essential for embryonic development and the maintenance of genomic stability (PubMed ID: 26658019 )
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： Cdk12 is essential for embryonic development and the maintenance of genomic stability (PubMed ID: 26658019 )
Construct Map ：
 
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