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RMRC No. RMRC13349 Order
Strain/Stock Designation B6.129S6-Zfyve9tm1Yty/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2018/1/22
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1. A targeting vector was generated in which exon 2 (FYVE domain located) of the Zfyve9 gene wereloxp-flanked. The construct was electroporated into 29S6/SvEvTac -derived TC1 embryonic stem (ES) cells.Blastocyst injection of ES cells carried targeted allele was used to obtain chimera. The chimeric males were crossed to C57BL/6 females.  The mice carried targeted allele were crossed with the mice carried protamine-cre transgene to delete exon 2 of Zfyve9 gene. The offspring was then backcrossed to C57BL/6 mice more than 10 generations.
2. Dysfunction of Zfyve9 genes promotes skin tumor formation and malignant progression.
Depositor ：
Yu-Ting Yan / 顏裕庭
Email ： yyan@ibms.sinica.edu.tw
Allele Symbol ： Zfyve9tm1Yty
Allele Name ： zinc finger, FYVE domain containing 9, target mutation 1, Yu-Ting Yan
Allele Description ：
Strain of Origin ： 129
Gene Symbol ： Zfyve9
Gene Name ： zinc finger, FYVE domain containing 9
Chromosome ： 4
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Cancer Cell and Developmental Biology
Construction Technologies ：
Cre-lox system FLP-FRT system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： PubMed ID: 25170969

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. PLoS One. 2014
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. PLoS One. 2014 Aug 29;9(8)
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email: yyan@ibms.sinica.edu.tw
Construct Map ：
 
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