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RMRC No. RMRC13353 Order
Strain/Stock Designation B6.129-Cdk12tm1FmjTrp53em1Fmj/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2019/3/26
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1. 
Trp53 mutation in this strain is generated by CRISPR/CAS9 technique and microinjection with embryos derived from strain B6.129-Cdk12tm1Fm j/Narl (RMRC13312)
2.  Deletion of Exon 3 to Exon 10 in Trp53 occurs in this strain
3.  Homozygous mutants often develop tumors (lymphomas and sarcomas) since three to six months of age.
4.  The breeding scheme used in this strain is homozygous mutant (Cdk12fl/flTrp53-/-) x homozygous mutant (Cdk12fl/flTrp53-/-).
Depositor ：
Ming-Ji Fann / 范明基
Email ： mjfann@ym.edu.tw
Allele Symbol ： Cdk12tm1Fmj
Allele Name ： cyclin-dependent kinase 12, target mutation 1, Ming-Ji Fann
Allele Description ：
Allele Symbol ： Trp53em1Fmj
Allele Name ： transformation related protein 53, endonuclease-mediated mutation 1, Ming-Ji Fann
Strain of Origin ： 129
Gene Symbol ： Cdk12
Gene Name ： cyclin-dependent kinase 12
Chromosome ： 11
Gene Symbol ： Trp53
Gene Name ： transformation related protein 53
Chromosome ： 11
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Cancer Cell and Developmental Biology
Construction Technologies ：
Cre-lox system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： homo x homo
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由Dr. Ming-Ji Fann 所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Dr. Ming-Ji Fann
Construct Map ：
 
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