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RMRC No. RMRC13436 Order
Strain/Stock Designation C57BL/6-Wwoxem2Dcwd/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2026/11/10
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ： WWOX KO#12
Background Strain ： C57BL/6
Strain Description ：
1.  A CRISPR/Cas9-mediated gene targeting strategy was employed to generate a conditional allele of the Wwox gene. The replacing DNA contained the loxP-flanked exon 1 of the Wwox gene, two single-guide RNAs (sgRNAs) targeting the 5’ upstream and intron1 of the Wwox gene were co-injected into the pronuclei of C57BL/6 (B6) zygotes. Founder mice carrying the partial deletion of exon 1 allele were subsequently bred with wild-type C57BL/6 mice to establish this line.
2.  Homozygous embryos were detected at embryonic day 15 in heterozygous intercrosses, but no homozygous offspring have been recovered after birth. (Revised by depositor, 20250613). 
Depositor ：
Dong Chuan, Wu / 吳東川
Email ： dongchuanwu@mail.cmu.edu.tw
Allele Symbol ： Wwoxem2Dcwd
Allele Name ： WW domain-containing oxidoreductase,endonuclease-mediated mutation 2,Dong Chuan, Wu
Allele Description ：
 
Strain of Origin ： C57BL/6
Gene Symbol ： Wwox
Gene Name ： WW domain-containing oxidoreductase
Chromosome ： 8
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Cardiovascular Neurobiology Research
Reproductive Biology
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由中國醫藥大學 吳東川所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge China Medical University Dong Chuan, Wu
Construct Map ：
 
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